Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts

Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts

Apolipoprotein A-I binding protein (AIBP) is a recently identified innate anti-inflammatory factor. Here, we show that AIBP inhibited HIV replication by targeting lipid rafts and reducing virus-cell fusion. Importantly, AIBP selectively reduced levels of rafts on cells stimulated by an inflammatory...

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Bibliographic Details
Main Authors: Larisa Dubrovsky, Adam Ward, Soo-Ho Choi, Tatiana Pushkarsky, Beda Brichacek, Christophe Vanpouille, Alexei A. Adzhubei, Nigora Mukhamedova, Dmitri Sviridov, Leonid Margolis, Richard B. Jones, Yury I. Miller, Michael Bukrinsky
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
hiv
aibp
nef
extracellular vesicles
exosomes
lipid rafts
fusion
hla
Online Access:https://doi.org/10.1128/mBio.02956-19

Internet

https://doi.org/10.1128/mBio.02956-19

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