Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

The generation and maturation of adult neural stem/progenitor cells are impaired in many neurodegenerative diseases, among them is Parkinson's disease (PD). In mammals, including humans, adult neurogenesis is a lifelong feature of cellular brain plasticity in the hippocampal dentate gyrus (DG)...

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Bibliographic Details
Main Authors: B. Winner, H.L. Melrose, C. Zhao, K.M. Hinkle, M. Yue, C. Kent, A.T. Braithwaite, S. Ogholikhan, R. Aigner, J. Winkler, M.J. Farrer, F.H. Gage
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
Neural progenitor cells
Neurogenesis
Parkinson's disease
Dendrites
Spines
LRRK2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110004018

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http://www.sciencedirect.com/science/article/pii/S0969996110004018

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