The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice

The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice

Extibacter muris is a newly described mouse gut bacterium which metabolizes cholic acid (CA) to deoxycholic acid (DCA) via 7α-dehydroxylation. Although bile acids influence metabolic and inflammatory responses, few in vivo models exist for studying their metabolism and impact on the host. Mice were...

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Bibliographic Details
Main Authors: Theresa Streidl, Isabel Karkossa, Rafael R. Segura Muñoz, Claudia Eberl, Alex Zaufel, Johannes Plagge, Robert Schmaltz, Kristin Schubert, Marijana Basic, Kai Markus Schneider, Mamdouh Afify, Christian Trautwein, René Tolba, Bärbel Stecher, Heidi L. Doden, Jason M. Ridlon, Josef Ecker, Tarek Moustafa, Martin von Bergen, Amanda E. Ramer-Tait, Thomas Clavel
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Gut Microbes
Subjects:
lipids
bile acids
gut microbiota
synthetic community
extibacter muris
7α-dehydroxylation
gut-liver axis
Online Access:http://dx.doi.org/10.1080/19490976.2020.1854008

Internet

http://dx.doi.org/10.1080/19490976.2020.1854008

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