Defective apical extrusion signaling contributes to aggressive tumor hallmarks

Defective apical extrusion signaling contributes to aggressive tumor hallmarks

When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P2 receptors in neighboring cells that seamlessly squeeze the cell out of the epithelium. Here, we find that extrusion defects can contri...

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Bibliographic Details
Main Authors: Yapeng Gu, Jill Shea, Gloria Slattum, Matthew A Firpo, Margaret Alexander, Sean J Mulvihill, Vita M Golubovskaya, Jody Rosenblatt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
epithelial
extrusion
carcinoma
invasion
pancreatic
tumor initiation
Online Access:https://elifesciences.org/articles/04069

Internet

https://elifesciences.org/articles/04069

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