In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection.

In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection.

Chagas disease is caused by infection with the intracellular protozoan parasite Trypanosoma cruzi. At present, nifurtimox and benznidazole, both compounds developed empirically over four decades ago, represent the chemotherapeutic arsenal for treating this highly neglected disease. However, both dru...

Full description

Bibliographic Details
Main Authors: Cristiane França da Silva, Denise da Gama Jaen Batista, Gabriel Melo Oliveira, Elen Mello de Souza, Erica Ripoll Hammer, Patricia Bernardino da Silva, Anissa Daliry, Julianna Siciliano Araujo, Constança Britto, Ana Carolina Mondaine Rodrigues, Zongying Liu, Abdelbasset A Farahat, Arvind Kumar, David W Boykin, Maria de Nazaré Correia Soeiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3264605?pdf=render

Internet

http://europepmc.org/articles/PMC3264605?pdf=render

Similar Items