Systematic, network-based characterization of therapeutic target inhibitors.

Systematic, network-based characterization of therapeutic target inhibitors.

A large fraction of the proteins that are being identified as key tumor dependencies represent poor pharmacological targets or lack clinically-relevant small-molecule inhibitors. Availability of fully generalizable approaches for the systematic and efficient prioritization of tumor-context specific...

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Bibliographic Details
Main Authors: Yao Shen, Mariano J Alvarez, Brygida Bisikirska, Alexander Lachmann, Ronald Realubit, Sergey Pampou, Jorida Coku, Charles Karan, Andrea Califano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5638208?pdf=render

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http://europepmc.org/articles/PMC5638208?pdf=render

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