Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses

Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses

Abstract The notion that T cell insulitis increases as type 1 diabetes (T1D) develops is unsurprising, however, the quantitative analysis of CD4+ and CD8+ T cells within the islet mass is complex and limited with standard approaches. Optical microscopy is an important and widely used method to evalu...

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Bibliographic Details
Main Authors: Alexander J. Dwyer, Jacob M. Ritz, Jason S. Mitchell, Tijana Martinov, Mohannad Alkhatib, Nubia Silva, Christopher G. Tucker, Brian T. Fife
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96327-2

Internet

https://doi.org/10.1038/s41598-021-96327-2

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