Sulfadoxine-pyrimethamine parasitological efficacy against Plasmodium falciparum among pregnant women and molecular markers of resistance in Zambia: an observational cohort study

Sulfadoxine-pyrimethamine parasitological efficacy against Plasmodium falciparum among pregnant women and molecular markers of resistance in Zambia: an observational cohort study

Abstract Background The World Health Organization recommends the provision of intermittent preventive treatment during pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) at 4-week intervals from gestational week 13 to delivery in areas of moderate to high malaria transmission intensity. However, t...

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Bibliographic Details
Main Authors: Enesia Banda Chaponda, Sungano Mharakurwa, Charles Michelo, Jane Bruce, Daniel Chandramoha, R. Matthew Chico
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Malaria Journal
Subjects:
Intermittent preventive treatment of malaria in pregnancy (IPTp)
Sulfadoxine-pyrimethamine (SP)
DHPS double mutation (gly-437 + glu-540)
DHFR triple mutation (asn-108 + ile-51 + arg-59)
Quintuple mutation (DHFR triple + DHPS double)
Sextuple mutation (DHFR triple + DHPS double + arg-581)
Online Access:https://doi.org/10.1186/s12936-021-03596-3

Internet

https://doi.org/10.1186/s12936-021-03596-3

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