Polyglutamine toxicity induces rod photoreceptor division, morphological transformation or death in Spinocerebellar ataxia 7 mouse retina

Polyglutamine toxicity induces rod photoreceptor division, morphological transformation or death in Spinocerebellar ataxia 7 mouse retina

In neurodegenerative disorders caused by polyglutamine (polyQ) expansion, polyQ toxicity is thought to trigger a linear cascade of successive degenerative events leading to neuronal death. To understand how neurons cope with polyQ toxicity, we studied a Spinocerebellar ataxia 7 (SCA7) mouse which ex...

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Bibliographic Details
Main Authors: Marina G. Yefimova, Nadia Messaddeq, Alice Karam, Carine Jacquard, Chantal Weber, Laurent Jonet, Uwe Wolfrum, Jean-Claude Jeanny, Yvon Trottier
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Polyglutamine
Neurodegeneration
Spinocerebellar ataxia 7
Photoreceptor
Proliferation
Remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002019

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http://www.sciencedirect.com/science/article/pii/S0969996110002019

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