Polyglutamine toxicity induces rod photoreceptor division, morphological transformation or death in Spinocerebellar ataxia 7 mouse retina
In neurodegenerative disorders caused by polyglutamine (polyQ) expansion, polyQ toxicity is thought to trigger a linear cascade of successive degenerative events leading to neuronal death. To understand how neurons cope with polyQ toxicity, we studied a Spinocerebellar ataxia 7 (SCA7) mouse which ex...
Main Authors: | Marina G. Yefimova, Nadia Messaddeq, Alice Karam, Carine Jacquard, Chantal Weber, Laurent Jonet, Uwe Wolfrum, Jean-Claude Jeanny, Yvon Trottier |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2010-10-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996110002019 |
Similar Items
-
Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion
by: Anna Niewiadomska-Cimicka, et al.
Published: (2020-06-01) -
Ophthalmic Manifestations and Genetics of the Polyglutamine Autosomal Dominant Spinocerebellar Ataxias: A Review
by: Jun Young Park, et al.
Published: (2020-08-01) -
Current Status of Gene Therapy Research in Polyglutamine Spinocerebellar Ataxias
by: Ricardo Afonso-Reis, et al.
Published: (2021-04-01) -
Cognitive Changes in the Spinocerebellar Ataxias Due to Expanded Polyglutamine Tracts: A Survey of the Literature
by: Evelyn Lindsay, et al.
Published: (2017-07-01) -
Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions
by: A. N. Shuvaev, et al.
Published: (2019-07-01)