Human organoid biofilm model for assessing antibiofilm activity of novel agents

Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with...

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Bibliographic Details
Main Authors: Bing (Catherine) Wu, Evan F. Haney, Noushin Akhoundsadegh, Daniel Pletzer, Michael J. Trimble, Alwin E. Adriaans, Peter H. Nibbering, Robert E. W. Hancock
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-020-00182-4