The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

Abstract Current evidence indicating a role of the human prion protein (PrP) in amyloid-beta (Aβ) formation or a synergistic effect between Aβ and prion pathology remains controversial. Conflicting results also concern the frequency of the association between the two protein misfolding disorders and...

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Bibliographic Details
Main Authors: Marcello Rossi, Hideaki Kai, Simone Baiardi, Anna Bartoletti-Stella, Benedetta Carlà, Corrado Zenesini, Sabina Capellari, Tetsuyuki Kitamoto, Piero Parchi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
Creutzfeldt-Jakob disease
Prion disease
Prion strain
Aβ-pathology
Tau-pathology
CAA
Online Access:http://link.springer.com/article/10.1186/s40478-019-0706-6

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http://link.springer.com/article/10.1186/s40478-019-0706-6

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