Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation

Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation

Abstract Background In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas GAREM2 is mainly expressed in the brain. However, the precise mechanism...

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Bibliographic Details
Main Authors: Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan, Hiroaki Konishi
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
Adaptor protein
Protein aggregation
Glycine-rich
EGF receptor
Tyrosine phosphorylation
Online Access:https://doi.org/10.1186/s11658-021-00260-1

Internet

https://doi.org/10.1186/s11658-021-00260-1

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