Combined CCNE1 high‐level amplification and overexpression is associated with unfavourable outcome in tubo‐ovarian high‐grade serous carcinoma

Combined CCNE1 high‐level amplification and overexpression is associated with unfavourable outcome in tubo‐ovarian high‐grade serous carcinoma

Abstract CCNE1 amplification is a recurrent alteration associated with unfavourable outcome in tubo‐ovarian high‐grade serous carcinoma (HGSC). We aimed to investigate whether immunohistochemistry (IHC) can be used to identify CCNE1 amplification status and to validate whether CCNE1 high‐level ampli...

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Bibliographic Details
Main Authors: Angela MY Chan, Emeka Enwere, John B McIntyre, Holly Wilson, Chidera Nwaroh, Nicholas Wiebe, Young Ou, Shuhong Liu, Katharina Wiedemeyer, Peter F Rambau, Xin Grevers, Donald G Morris, Paola Neri, C Blake Gilks, Frank Visser, Nhu Le, Li Luo, Linda S Cook, Martin Köbel
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:The Journal of Pathology: Clinical Research
Subjects:
ovarian cancer
high grade serous carcinoma
CCNE1
cyclin E1
amplification
prognosis
Online Access:https://doi.org/10.1002/cjp2.168

Internet

https://doi.org/10.1002/cjp2.168

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