Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunction

Abstract Preclinical diastolic dysfunction (PDD) results in impaired cardiorenal response to volume load (VL) which may contribute to the progression to clinical heart failure with preserved ejection fraction (HFpEF). The objective was to evaluate if phosphodiesterase V inhibition (PDEVI) alone or c...

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Bibliographic Details
Main Authors: Siu‐Hin Wan, Paul M. McKie, Joshua P. Slusser, John C. Burnett Jr, David O. Hodge, Horng H. Chen
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Physiological Reports
Online Access:https://doi.org/10.14814/phy2.14974