SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation

SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation

Abstract Background Polarity is necessary for epithelial cells to perform distinct functions at their apical and basal surfaces. Oral epithelial cell-derived ameloblasts at secretory stage (SABs) synthesize large amounts of enamel matrix proteins (EMPs), largely amelogenins. EMPs are unidirectionall...

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Bibliographic Details
Main Authors: Yan Zhang, Liwei Zheng, Michael Le, Yukiko Nakano, Barry Chan, Yulei Huang, Parisa Moravedje Torbaty, Yoshinori Kohwi, Ralph Marcucio, Stefan Habelitz, Pamela K. Den Besten, Terumi Kohwi-Shigematsu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Biology
Subjects:
Ameloblast
Enamel
Special AT-rich sequence-binding protein-1 (SATB1)
Amelogenin
Claudin 1
Tight junction
Online Access:https://doi.org/10.1186/s12915-019-0722-9

Internet

https://doi.org/10.1186/s12915-019-0722-9

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