Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Abstract Background Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and antibody-based cytometry. Here, we present a multi-omics approac...

Full description

Bibliographic Details
Main Authors: Dominik Trzupek, Melanie Dunstan, Antony J. Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B. Rainbow, Dominik Aschenbrenner, Joanne L. Jones, Holm H. Uhlig, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Genome Medicine
Subjects:
Single-cell RNA sequencing (scRNA-seq)
Multi-omics
CD4+ T cells
AbSeq
Immunophenotyping
CD80
Online Access:http://link.springer.com/article/10.1186/s13073-020-00756-z

Internet

http://link.springer.com/article/10.1186/s13073-020-00756-z

Similar Items