Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules

Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules

The aim of the study is to clarify the role of hypoxia-inducible factor-1 (HIF-1) in the development of renal fibrosis in mouse obstructive nephropathy. We used mice with floxed HIF-1α alleles and tamoxifen-inducible Cre/ERT2 recombinase under ubiquitin C promoter to induce global HIF-1α deletion. F...

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Bibliographic Details
Main Authors: Kazuya Kabei, Yu Tateishi, Masakazu Nozaki, Masako Tanaka, Masayuki Shiota, Mayuko Osada-Oka, Shunji Nishide, Junji Uchida, Tatsuya Nakatani, Shuhei Tomita, Katsuyuki Miura
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Hypoxia-inducible factor
Hypoxia
Renal fibrosis
HIF-1α
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317302074

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http://www.sciencedirect.com/science/article/pii/S1347861317302074

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