Weinreb Amidation as the Cornerstone of an Improved Synthetic Route to A-Ring-Modified Derivatives of Luotonin A

Weinreb Amidation as the Cornerstone of an Improved Synthetic Route to A-Ring-Modified Derivatives of Luotonin A

Weinreb amidation of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate with aromatic amines provides a significantly improved route to anilide-type key intermediates for the synthesis of the anticancer alkaloid, luotonin A, and new A-ring-modified derivatives thereof. This method has advantages conce...

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Bibliographic Details
Main Authors: Norbert Haider, Simon Nuß
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Molecules
Subjects:
Weinreb amidation
luotonin A
[4+2] cycloaddition
thiophene
Online Access:http://www.mdpi.com/1420-3049/17/10/11363

Internet

http://www.mdpi.com/1420-3049/17/10/11363

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