Much ado about nothing? Off-target amplification can lead to false-positive bacterial brain microbiome detection in healthy and Parkinson’s disease individuals

Much ado about nothing? Off-target amplification can lead to false-positive bacterial brain microbiome detection in healthy and Parkinson’s disease individuals

Abstract Background Recent studies suggested the existence of (poly-)microbial infections in human brains. These have been described either as putative pathogens linked to the neuro-inflammatory changes seen in Parkinson’s disease (PD) and Alzheimer’s disease (AD) or as a “brain microbiome” in the c...

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Bibliographic Details
Main Authors: Janis R. Bedarf, Naiara Beraza, Hassan Khazneh, Ezgi Özkurt, David Baker, Valeri Borger, Ullrich Wüllner, Falk Hildebrand
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Microbiome
Subjects:
Microbiome
Brain
Brain-microbiome
16S rRNA gene
Next generation sequencing
Bacterial infection
Online Access:https://doi.org/10.1186/s40168-021-01012-1

Internet

https://doi.org/10.1186/s40168-021-01012-1

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