NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness.

NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness.

BACKGROUND:The psychotomimetics ketamine and MK-801, non-competitive NMDA receptor (NMDAr) antagonists, induce cognitive impairment and aggravate schizophrenia symptoms. In conscious rats, they produce an abnormal behavior associated with a peculiar brain state characterized by increased synchroniza...

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Bibliographic Details
Main Authors: Tahir Hakami, Nigel C Jones, Elena A Tolmacheva, Julien Gaudias, Joseph Chaumont, Michael Salzberg, Terence J O'Brien, Didier Pinault
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2727800?pdf=render

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http://europepmc.org/articles/PMC2727800?pdf=render

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