Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumpin...

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Bibliographic Details
Main Authors: Alfredo Cabrera-Orefice, Etienne Galemou Yoga, Christophe Wirth, Karin Siegmund, Klaus Zwicker, Sergio Guerrero-Castillo, Volker Zickermann, Carola Hunte, Ulrich Brandt
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06955-y

Internet

https://doi.org/10.1038/s41467-018-06955-y

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