No Early Effect of Intrathecal Rituximab in Progressive Multiple Sclerosis (EFFRITE Clinical Trial)

Background. The progressive phase of multiple sclerosis (MS) is characterized by an intrathecal (IT) compartmentalization of inflammation, involving B-cells within meningeal follicles, and resisting all the available immunosuppressive treatments. A new therapeutic paradigm may be to target this infl...

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Bibliographic Details
Main Authors: Mickael Bonnan, Sylvie Ferrari, Henri Courtade, Paul Money, Pauline Desblache, Bruno Barroso, Stéphane Debeugny
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Multiple Sclerosis International
Online Access:http://dx.doi.org/10.1155/2021/8813498