Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway

Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway

Liver fibrosis is an important stage in the progression of liver injury into cirrhosis or even liver cancer. Hepatic stellate cells (HSCs) are induced by transforming growth factor-β1 (TGF-β1) to produce α-smooth muscle actin (α-SMA) and collagens in liver fibrosis. Butaselen (BS), which was previou...

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Bibliographic Details
Main Authors: Wenxuan Jiao, Man Bai, Hanwei Yin, Jiayi Liu, Jing Sun, Xiaoxia Su, Huihui Zeng, Jinhua Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
liver fibrosis
hepatic stellate cells
thioredoxin reductase
transforming growth factor-β1
collagen
α-SMA
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.690170/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.690170/full

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