Activin A backs-up TGF-ß to promote regulatory T cells

Activin A backs-up TGF-ß to promote regulatory T cells

The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade o...

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Bibliographic Details
Main Authors: Mara De Martino, Camille Daviaud, Claire Vanpouille-Box
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
activin a
immunosuppression
tgf-beta
radiotherapy
regulatory t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1883288

Internet

http://dx.doi.org/10.1080/2162402X.2021.1883288

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