Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection

Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection

Anaplasma phagocytophilum infects neutrophils to cause granulocytic anaplasmosis, an emerging potentially fatal disease and the second-most common tick-borne illness in the United States. Treatment options are limited, and no vaccine exists. Due to the bacterium’s obligatory intracellular lifestyle,...

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Bibliographic Details
Main Authors: Ryan S. Green, Waheeda A. Naimi, Lee D. Oliver, Nathaniel O’Bier, Jaehyung Cho, Daniel H. Conrad, Rebecca K. Martin, Richard T. Marconi, Jason A. Carlyon
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
adhesin
anaplasma phagocytophilum
obligate intracellular bacteria
protein disulfide isomerase
host-pathogen interactions
Online Access:https://doi.org/10.1128/mBio.03141-19

Internet

https://doi.org/10.1128/mBio.03141-19

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