Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis

Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis

Management of oxaliplatin-induced peripheral neuropathy (OIPN) has proven challenging owing to the concern that any OIPN-preventing agents may also decrease the efficacy of the chemotherapeutic agent and fail to reverse established neuronal damage. Nevertheless, targeting redox signaling pathways co...

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Bibliographic Details
Main Authors: Yuan Fang, Juan Ye, Bing Zhao, Jinbing Sun, Na Gu, Xi Chen, Lingli Ren, Jiao Chen, Xueting Cai, Wenjuan Zhang, Yang Yang, Peng Cao
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Formononetin
Oxaliplatin-induced peripheral neuropathy
NRF2
KEAP1
GSTP1
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172030882X

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http://www.sciencedirect.com/science/article/pii/S221323172030882X

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