Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insight into the role of H3-G34R, we generated fission y...

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Bibliographic Details
Main Authors: Rajesh K Yadav, Carolyn M Jablonowski, Alfonso G Fernandez, Brandon R Lowe, Ryan A Henry, David Finkelstein, Kevin J Barnum, Alison L Pidoux, Yin-Ming Kuo, Jie Huang, Matthew J O’Connell, Andrew J Andrews, Arzu Onar-Thomas, Robin C Allshire, Janet F Partridge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
cancer
chromatin
homologous recombination
H3K36
Online Access:https://elifesciences.org/articles/27406

Internet

https://elifesciences.org/articles/27406

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