Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma

Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma

Subodh Kumar et al. identify a gene signature correlated with genomic instability and poor survival in esophageal adenocarcinoma (EAC), using a combination of integrative genomic analysis of patient data and laboratory validation in cell line models and mice. They find that inhibitors of some of the...

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Bibliographic Details
Main Authors: Subodh Kumar, Leutz Buon, Srikanth Talluri, Marco Roncador, Chengcheng Liao, Jiangning Zhao, Jialan Shi, Chandraditya Chakraborty, Gabriel Gonzalez, Yu-Tzu Tai, Rao Prabhala, Mehmet K. Samur, Nikhil C. Munshi, Masood A. Shammas
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02125-x

Internet

https://doi.org/10.1038/s42003-021-02125-x

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