The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response
Abstract MITA (also known as STING) is an ER-located adaptor protein, which mediates DNA-triggered innate immune response and is critically involved in autoimmune diseases and tumorigenesis. MITA is regulated by post-translational modifications, but how post-transcriptional mechanisms are involved i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-021-00277-y |