Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy

Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy

Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America. Thirty percent of infected individuals develop chronic Chagas cardiomyopathy (CCC), an inflammatory dilated cardiomyopathy that is the most important clinical consequence of T. cruzi infection, while...

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Bibliographic Details
Main Authors: Amanda Farage Frade-Barros, Barbara Maria Ianni, Sandrine Cabantous, Cristina Wide Pissetti, Bruno Saba, Hui Tzu Lin-Wang, Paula Buck, José Antonio Marin-Neto, André Schmidt, Fabrício Dias, Mario Hiroyuki Hirata, Marcelo Sampaio, Abílio Fragata, Alexandre Costa Pereira, Eduardo Donadi, Virmondes Rodrigues, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
Chagas disease
cardiomyopathy
susceptibility
IL12
IL 10
IFN
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01386/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01386/full

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