Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

Objective: Insulin resistance is a key feature of Type 2 Diabetes (T2D), and improving insulin sensitivity is important for disease management. Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal...

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Bibliographic Details
Main Authors: Simon A. Hinke, Anne M. Cieniewicz, Thomas Kirchner, Katharine D'Aquino, Rupesh Nanjunda, Jason Aligo, Robert Perkinson, Philip Cooper, Ken Boayke, Mark L. Chiu, Steve Jarantow, Eilyn R. Lacy, Yin Liang, Dana L. Johnson, Jean M. Whaley, Russell B. Lingham, Anthony J. Kihm
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817307950

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http://www.sciencedirect.com/science/article/pii/S2212877817307950

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