Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-α-Induced NF-κB Activation

Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-α-Induced NF-κB Activation

Twenty-three new berberine (BBR) analogues defined on substituents of ring D were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure–activity relationship (SAR) analysis indicated that suitable tertiary/q...

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Bibliographic Details
Main Authors: Yan-Xiang Wang, Lu Liu, Qing-Xuan Zeng, Tian-Yun Fan, Jian-Dong Jiang, Hong-Bin Deng, Dan-Qing Song
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
berberine
anti-inflammatory
NF-κB
IκB kinase
structure-activity relationship
Online Access:https://www.mdpi.com/1420-3049/22/8/1257

Internet

https://www.mdpi.com/1420-3049/22/8/1257

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