A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice.

Bibliographic Details
Main Authors: Tyler R. Schleicher, Jing Yang, Marianna Freudzon, Alison Rembisz, Samuel Craft, Madeleine Hamilton, Morven Graham, Godfree Mlambo, Abhai K. Tripathi, Yue Li, Peter Cresswell, Photini Sinnis, George Dimopoulos, Erol Fikrig
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05374-3