A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice.

Bibliographic Details
Main Authors: Tyler R. Schleicher, Jing Yang, Marianna Freudzon, Alison Rembisz, Samuel Craft, Madeleine Hamilton, Morven Graham, Godfree Mlambo, Abhai K. Tripathi, Yue Li, Peter Cresswell, Photini Sinnis, George Dimopoulos, Erol Fikrig
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05374-3
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spelling doaj-6f1de94305704e90b23021c6aaa9d4132021-05-11T10:18:22ZengNature Publishing GroupNature Communications2041-17232018-07-019111210.1038/s41467-018-05374-3A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmissionTyler R. Schleicher0Jing Yang1Marianna Freudzon2Alison Rembisz3Samuel Craft4Madeleine Hamilton5Morven Graham6Godfree Mlambo7Abhai K. Tripathi8Yue Li9Peter Cresswell10Photini Sinnis11George Dimopoulos12Erol Fikrig13Section of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineDepartment of Dermatology, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineYale Center for Cellular and Molecular Imaging, Yale University School of MedicineDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Immunobiology, Yale University School of MedicineDepartment of Immunobiology, Yale University School of MedicineDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversitySection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineMosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice.https://doi.org/10.1038/s41467-018-05374-3
collection DOAJ
language English
format Article
sources DOAJ
author Tyler R. Schleicher
Jing Yang
Marianna Freudzon
Alison Rembisz
Samuel Craft
Madeleine Hamilton
Morven Graham
Godfree Mlambo
Abhai K. Tripathi
Yue Li
Peter Cresswell
Photini Sinnis
George Dimopoulos
Erol Fikrig
spellingShingle Tyler R. Schleicher
Jing Yang
Marianna Freudzon
Alison Rembisz
Samuel Craft
Madeleine Hamilton
Morven Graham
Godfree Mlambo
Abhai K. Tripathi
Yue Li
Peter Cresswell
Photini Sinnis
George Dimopoulos
Erol Fikrig
A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
Nature Communications
author_facet Tyler R. Schleicher
Jing Yang
Marianna Freudzon
Alison Rembisz
Samuel Craft
Madeleine Hamilton
Morven Graham
Godfree Mlambo
Abhai K. Tripathi
Yue Li
Peter Cresswell
Photini Sinnis
George Dimopoulos
Erol Fikrig
author_sort Tyler R. Schleicher
title A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
title_short A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
title_full A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
title_fullStr A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
title_full_unstemmed A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
title_sort mosquito salivary gland protein partially inhibits plasmodium sporozoite cell traversal and transmission
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-07-01
description Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice.
url https://doi.org/10.1038/s41467-018-05374-3
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