Dental effects of enzyme replacement therapy in case of childhood-type hypophosphatasia

Dental effects of enzyme replacement therapy in case of childhood-type hypophosphatasia

Abstract Background Hypophosphatasia (HPP), a skeletal disease characterized by hypomineralization of bone and teeth, is caused by an ALPL gene mutation that leads to low activity of the tissue non-specific alkaline phosphatase enzyme. Although enzyme replacement therapy (ERT) was recently introduce...

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Bibliographic Details
Main Authors: Rena Okawa, Kazuma Kokomoto, Kazuhiko Nakano
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Oral Health
Subjects:
Hypophosphatasia
Enzyme replacement therapy
Hypomineralization
Dental age
Mandibular bone density
Online Access:https://doi.org/10.1186/s12903-021-01673-2

Internet

https://doi.org/10.1186/s12903-021-01673-2

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