Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

All metazoans that utilize molecular oxygen (O<sub>2</sub>) for metabolic purposes have the capacity to adapt to hypoxia, the condition that arises when O<sub>2</sub> demand exceeds supply. This is mediated through activation of the hypoxia-inducible factor (HIF) pathway. At...

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Bibliographic Details
Main Authors: Moritz J. Strowitzki, Eoin P. Cummins, Cormac T. Taylor
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
hypoxia
prolyl hydroxylation
hypoxia-inducible factor
mass spectrometry
HIF-prolyl hydroxylases
factor inhibiting HIF
Cep192
IKK-β
p105
p53
FOXO3a
OTUB1
MAPK6
RIPK4
Online Access:https://www.mdpi.com/2073-4409/8/5/384

Internet

https://www.mdpi.com/2073-4409/8/5/384

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