Hepatic triglyceride lipase promotes low density lipoprotein receptor-mediated catabolism of very low density lipoproteins in vitro

Hepatic triglyceride lipase promotes low density lipoprotein receptor-mediated catabolism of very low density lipoproteins in vitro

We demonstrate here that hepatic triglyceride lipase (HTGL) enhances VLDL degradation in cultured cells by a LDL receptor-mediated mechanism. VLDL binding at 4°C and degradation at 37°C by normal fibroblasts was stimulated by HTGL in a dose-dependent manner. A maximum increase of up to 7-fold was se...

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Bibliographic Details
Main Authors: Jheem D. Medh, Susan L. Bowen, Glenna L. Fry, Stacie Ruben, John Hill, Howard Wong, David A. Chappell
Format: Article
Language:English
Published: Elsevier 1999-07-01
Series:Journal of Lipid Research
Subjects:
hepatic lipase
lipoprotein lipase
LDL receptor
LDL receptor-related protein
heparan sulfate proteoglycans
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752033488X

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http://www.sciencedirect.com/science/article/pii/S002222752033488X

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