Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients

Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease, which currently lacks specific diagnostic biomarkers. The diversity within the patients obstructs clinical trials but may also reflect differences in underlying pathogenesis. Our objective was to obtain protein profiles to ide...

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Main Authors: Helena Idborg, Arash Zandian, Elena Ossipova, Edvard Wigren, Charlotta Preger, Fariborz Mobarrez, Antonio Checa, Azita Sohrabian, Pascal Pucholt, Johanna K. Sandling, Cátia Fernandes-Cerqueira, Johan Rönnelid, Vilija Oke, Giorgia Grosso, Marika Kvarnström, Anders Larsson, Craig E. Wheelock, Ann-Christine Syvänen, Lars Rönnblom, Kim Kultima, Helena Persson, Susanne Gräslund, Iva Gunnarsson, Peter Nilsson, Elisabet Svenungsson, Per-Johan Jakobsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
Interferon regulating factor 5 (IRF5)
antibody suspension bead arrays
subgroups
biomarker discovery
plasma proteomics
unsupervised clustering
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01029/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01029/full

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