Sirtuins in Alzheimer’s Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics

Sirtuins in Alzheimer’s Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics

Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular stress response, metabolism and aging. Sirtuins are components of the epigenetic machinery, which is disturbed in...

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Bibliographic Details
Main Authors: Ramón Cacabelos, Juan C. Carril, Natalia Cacabelos, Aleksey G. Kazantsev, Alex V. Vostrov, Lola Corzo, Pablo Cacabelos, Dmitry Goldgaber
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
APOE
CYP2D6
epigenetics
genophenotypes
multifactorial treatment
pharmacoepigenetics
pharmacogenetics
sirtuins 1–7
SIRT2
Online Access:http://www.mdpi.com/1422-0067/20/5/1249

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http://www.mdpi.com/1422-0067/20/5/1249

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