Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia

Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia

Large granular lymphocyte leukemia (LGLL) is a chronic proliferation of clonal cytotoxic lymphocytes, usually presenting with cytopenias and yet lacking a specific therapy. The disease is heterogeneous, including different subsets of patients distinguished by LGL immunophenotype (CD8+ Tαβ, CD4+ Tαβ,...

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Bibliographic Details
Main Authors: Antonella Teramo, Gregorio Barilà, Giulia Calabretto, Cristina Vicenzetto, Vanessa Rebecca Gasparini, Gianpietro Semenzato, Renato Zambello
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
large granular lymphocyte (LGL)
T-LGL leukemia (T-LGLL)
chronic lymphoproliferative disease of NK cells (CLPD-NK)
STAT3
STAT5b
mutation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00152/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00152/full

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