Experimental and Simulation Identification of Xanthohumol as an Inhibitor and Substrate of ABCB1

Experimental and Simulation Identification of Xanthohumol as an Inhibitor and Substrate of ABCB1

Xanthohumol (XN) is a well-known prenylated flavonoid found in Humulus lupulus L. It is involved in several pharmacological activities, including the sensitization of doxorubicin-resistant breast cancer (MCF-7/ADR) cells to doxorubicin (DOX) through a reduction in cell viability and stemness. In the...

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Bibliographic Details
Main Authors: Fangming Liu, Hannah Hoag, Chun Wu, Haizhou Liu, Hua Yin, Jianjun Dong, Zhonghua Qian, Feng Miao, Ming Liu, Jinlai Miao
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Applied Sciences
Subjects:
xanthohumol
doxorubicin resistance
synergism
ABCB1
Online Access:http://www.mdpi.com/2076-3417/8/5/681

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http://www.mdpi.com/2076-3417/8/5/681

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