A Systems Biology Approach Identifies Hidden Regulatory Connections Between the Circadian and Cell-Cycle Checkpoints

Circadian rhythms form a self-sustaining, endogenous, time-keeping system that allows organisms to anticipate daily environmental changes. The core of the clock network consists of interlocking transcriptional-translational feedback loops that ensures that metabolic, behavioral, and physiological pr...

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Bibliographic Details
Main Authors: Xianlin Zou, Dae Wook Kim, Tetsuya Gotoh, Jingjing Liu, Jae Kyoung Kim, Carla V. Finkielstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
p53
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00327/full