NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this study we demonstrate that TP63 directly regulates NRG...

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Bibliographic Details
Main Authors: Ganapati V Hegde, Cecile de la Cruz, Jennifer M Giltnane, Lisa Crocker, Avinashnarayan Venkatanarayan, Gabriele Schaefer, Debra Dunlap, Joerg D Hoeck, Robert Piskol, Florian Gnad, Zora Modrusan, Frederic J de Sauvage, Christian W Siebel, Erica L Jackson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
NRG1
ERBB3
TP63
squamous cell cancer
Online Access:https://elifesciences.org/articles/46551

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