Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling.

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling.

Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to cellular dysfunction or is protective is unknown...

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Bibliographic Details
Main Authors: Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6085068?pdf=render

Internet

http://europepmc.org/articles/PMC6085068?pdf=render

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