(R,S)-Ketamine Promotes Striatal Neurogenesis and Sensorimotor Recovery Through Improving Poststroke Depression–Mediated Decrease in Atrial Natriuretic Peptide

(R,S)-Ketamine Promotes Striatal Neurogenesis and Sensorimotor Recovery Through Improving Poststroke Depression–Mediated Decrease in Atrial Natriuretic Peptide

Background: Poststroke social isolation could worsen poststroke depression and dampen neurogenesis. (R,S)-ketamine has antidepressant and neuroprotective effects; however, its roles and mechanisms in social isolation–mediated depressive-like behaviors and sensorimotor recovery remain unclear. Method...

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Bibliographic Details
Main Authors: Yujing Zhang, Bing Xie, Yin Yuan, Ting Zhou, Ping Xiao, Yuming Wu, You Shang, Shiying Yuan, Jiancheng Zhang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biological Psychiatry Global Open Science
Subjects:
Atrial natriuretic peptide
Neurogenesis
Poststroke depression
(R,S)-ketamine
Social isolation
Transforming growth factor-β
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174321000082

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http://www.sciencedirect.com/science/article/pii/S2667174321000082

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