The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

Abstract Objective Diabetic nephropathy (DN) is characterized by glomerular and tubulointerstitial injury, proteinuria and remodeling. Here we examined whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degrading enzyme, and an angiotensin II type 1 receptor bl...

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Bibliographic Details
Main Authors: Javad Habibi, Annayya R. Aroor, Nitin A. Das, Camila M. Manrique-Acevedo, Megan S. Johnson, Melvin R. Hayden, Ravi Nistala, Charles Wiedmeyer, Bysani Chandrasekar, Vincent G. DeMarco
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cardiovascular Diabetology
Subjects:
Obesity
Diabetes
Glomerular injury
Tubular injury
Neprilysin inhibition
Online Access:http://link.springer.com/article/10.1186/s12933-019-0847-8

Internet

http://link.springer.com/article/10.1186/s12933-019-0847-8

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