HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers.

HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers.

Subclinical endotoxemia has been reported in HIV-1 infected persons and may drive systemic immune activation and pathogenesis. Proinflammatory responsiveness to endotoxin (LPS) is mediated by Toll-like receptor 4 (TLR4). We therefore examined the association between plasma LPS levels, HIV RNA, and T...

Full description

Bibliographic Details
Main Authors: Richard T Lester, Xiao-Dan Yao, T Blake Ball, Lyle R McKinnon, Were R Omange, Rupert Kaul, Charles Wachihi, Walter Jaoko, Kenneth L Rosenthal, Francis A Plummer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2680984?pdf=render

Internet

http://europepmc.org/articles/PMC2680984?pdf=render

Similar Items