High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility

High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility

Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and haplotypes. We genotyped 11 HLA genes in 477 non-Hispanic European MS patients and their 954 unaffected parents using a validated next-generation sequencing (NGS) methodology. HLA haplotypes were assigned u...

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Bibliographic Details
Main Authors: Kazutoyo Osoegawa, Lisa E. Creary, Gonzalo Montero-Martín, Kalyan C. Mallempati, Sridevi Gangavarapu, Stacy J. Caillier, Adam Santaniello, Noriko Isobe, Jill A. Hollenbach, Stephen L. Hauser, Jorge R. Oksenberg, Marcelo A. Fernández-Viňa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis (MS)
family
HLA
haplotype
transmission disequilibrium test (TDT)
case-control analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.644838/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.644838/full

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