DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation

DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation

Pressure overload leads to a hypertrophic milieu that produces deleterious cardiac dysfunction. Inflammation is a key pathophysiological mechanism underpinning myocardial hypertrophy. DL-3-n-butylphthalide (NBP), a neuroprotective agent, also has potent cardioprotective effects. In this study, the p...

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Bibliographic Details
Main Authors: Bingjiang Han, Jiajun Xu, Xiaowen Shi, Zhanxiong Zheng, Fengjie Shi, Fenfen Jiang, Jibo Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
dl-3-n-butylphthalide
myocardial hypertrophy
GSDMD
inflammation
target
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.688140/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.688140/full

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